Disinfectant, antiseptic, and healing medium



Patented Dec. 17, 1929 UNITED STATES PATENT OFFICE OTTO GERNGROSS, OF BERLIN-GRUNEWALD, AND -KURT RfiL KE, 0F CHARLOTTENBUIRG,

GERMANY, ASSIGNORS, BY MESNE ASSIGNMENTS, TO KALI-CHEI'IIIE A. (3., OF BER- LIN, GERMANY DISINFECTANT, ANTISEPTIG, AND HEALING :MEDIUTM No Drawing. Application filed March 9, 1925, Serial No. 14,275, and in Germany June 27, 1924.

tic and healing efiects are very materially increased. The activating effect of the thiocyanogen compounds particularly shows itself to advantage more particularly in the presence of albuminous substances, mucilage and the like.

As disinfecting or antiseptic media capable of being activated there come into consideration organic compounds oft-he most varied kind, for example alcohols, such as ethyl alcohol, isopropyl alcohol and the like, compounds containing phenolic bodies and their derivatives, such as phenol, sodium chlorometacresol, guaiacol and hydroxyquinoline,

aldehydes, such as formaldehyde, heterocyclic compounds such as 1-pheny1-2, 3-dimethyl-5-pyrazolon and quinine, and terpenes and their derivatives, such for example as tGIXlIlBOl, oil of cloves and the like.

s activating compounds there come into consideration those of the lightmetals, particularly those of the alkali metals, including ammonium, and of the alkaline earthim'etals,

- including magnesium. The quantity of the thiocyanogen compounds to be added may vary within wide limits. It may under some circumstances be very high in relationto-the quantity of the organic body to be .activated. The additions of alkali metal thiocyanate and the like requisite for obtaining the best results are settled according to the nature of the medium to be activated, according to the concentration of the solutions, mixtures, triturations and the like to be employed, according to the object in view, and so forth. When employing the disinfecting medium in the presenceof albumin the addition of alkali metal thiocyanate and the like is referably effected in such quantities that t ie utmost possible steeping and liquefying action is exerted upon the albumin and related substances.

F or the purpose of manufacturing the disinfecting medium one may for example proceed by bringing together the initial mate rials by convertlng sodium chloro-metacresoland potassium thiocyanate into an aqueous solution. One may for example proceed by introducing the components together or successively into a solvent, or by first'prcparing mixtures that contain the constituents in suitable quantities, and then cbnverting these into such suitable forms as are desired for use, such as solutions, suspenions, salves, pastes, sticks or the like. One may also for example proceed by first grinding down one component for example with an ointment base, and then adding the other. In given cases one may also combine a number of dis infectants with one another, and activate the mixture thereof by the aid of thiocyanogen compounds, or combine a number of thiocy- 'anogen compounds with one or more disinmay also be incorporated with the disinfectin tu ed according to the invention, particularly such as are usual in the manufacture of remedies and disinfectants, such for example as saponin, starch, dextrine and the like.

Besides the increases in effectiveness as regards disinfectant and antiseptic actions obtainable owing to the presence of thiocyanogen compounds, the invention also presents other advantages in other directions. Thus the combination of expensive disinfectants with cheap thiocyanogen compounds involves a. cheapening, inasmuch as while employing smaller quantities of the dearer organic compounds, equal and even enhanced results can be obtained.

I Ewamples (1) 1 part of phenol is mixed with 4 parts of ammonium thiocyanate and 200 parts of water.

(2) 1 partof 1'-phenyl-2, 3-dimethyl-5 pyrazolon with 2 parts of potassium thiocyanate are finely powdered and mixed toantiseptic and healing media manufacgether. The product is employed in the form of tablets, to which also taste correctives may be added.

(3) 2% parts of 40 per cent formaldehyde are introduced into an aqueous solution of 8 parts of KCN-S the whole made up to 200 cubic centimetres with Water, to which perfumes and flavouring substances may be added, and diluted with Water before use if desired.

It is already known that by means of alkali metal thiocyanates and alkaline earth metal thio'cyanates gelatine can be protected against the tendency of formaldehyde to cause flocculent precipitation, and can thereby be kept in solution. In the case of this process the thiocyanogen salt is the protecting means for the gelatine. The addition must therefore be effected in the quantities requisite for obtaining this protective action. Accordingly.

the present invention is based on the new dlscovery that thiocyanogen salts are capable of materially enhancing the disinfecting and antiseptic action of organic disinfectants. The addition has therefore to be made in the case of the present inventlon 1n such quantities that the utmostpossible increase in effect is obtained. The combination of thiocyanogen salt, gelatine and formaldehyde is excluded from the present invention.

' \Vhat We claim is 1. A disinfecting, antiseptic and healing medium comprising at least one organic disinfecting compound and at least one thiocyanogen compound adapted to enhance the action of said organic disinfecting compounds.

2. A disinfecting, antiseptic and healing mediun comprising at least one organic disinfecting compound, at least one thiocyanogen compound adapted to enhance the action of said organic disinfecting compounds, and at least one substance having the property of reducing the surface tension of themedium.

3. A disinfecting, antiseptic and healing medium comprising at least one organic disinfecting compound and at least one thiocyanogen compound of a light metal.

4. A disinfecting, antiseptic and healing medium comprising at least one organic dislnfecting compound and at least one alkali metal thiocyanogen compound.

In testimony whereof We have signed our names to-this specification.

OTTO GERNGROSS. KURT RI'JLKE. 

